Schlieren, Zurich/Switzerland, September 24, 2024 - Mabylon AG, a leader in the high-throughput discovery, characterization, and development of human-derived antibodies, today announced that it has received three grants totaling more than CHF 1.3 million from Innosuisse Swiss Innovation Agency, Target ALS and the ALS Association.
The funding from Target ALS and the ALS Association is dedicated to advancing the development of human-derived TDP-43 intrabodies that restore normal TDP-43 function in patients with amyotrophic lateral sclerosis (ALS) by reducing pathological TDP-43 aggregates in diseased neurons.
„TDP-43 aggregates are a hallmark of ALS and have emerged as a prime target for treating both familial and sporadic forms of the disease," said Kuldip Dave, Ph.D., Senior Vice President of Research at the ALS Association. „We are excited to support the continued preclinical development of Mabylon AG's intrabody approach through our Lawrence and Isabel Barnett Drug Development Program. Getting ...
